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Are there any significant difference going from 50Hz to 60Hz systems, beside different physical components? I mean, is a distro panel in London going to be identical to one in New York, just with a different sticker on the breakers, or are different nations going to be completely different?

It seems the bigger the things get, the more similar they become. If you take two small panels, one to the east of the Atlantic and one to the west of it you will find:

US: A metal cabinet with steel conduit with the breakers placed horisontally
EU: A plastic box with cables with the breakers placed vertically.

If you open them you find different color schemes and two different busbar designs. If there is a busbar in the plastic box, that is. [Linked Image]