On an adressable system you typically run a 2 conductor fire wire, it is printed on the jacket FPLP. The data and power are on the same cable. If the panel does not have a two wire smoke zone you would need a four conductor, one pair for power the other to provide closure to the zone. You can also run thhn in emt and that is acceptable here in NJ, I don't see why it wouldn't be anywhere else. Your horn/strobes are normally run parallel with each other with end of the line supervision to make sure your nac is intact. If you go with a combination burg/fire panel all the signaling is done from one output but most of them can produce a different tone depending on what tripped the panel, eg solid tone for burg and pulsing for fire.
