The concept of more than one RG6 coax run to any location is pretty silly to say the least. RG6 is used for cable TV or satellite receivers and it's extremely rare that more than one run will ever be required unless the original run wasn't installed properly and it fails.
I would run 2 RG6s to at least the main living room tv and the basement High Def Big Screen why? because most of todays Satellite receivers have 2 inputs for dual tuners and the Hard drive for the PVR portion. Also with these units you can feed out to another TV location which requires another RG6 cable
