What I do to clean up the keyboard and mouse is to first shut down the machine (so keystrokes or mouse activity doesn't cause anything to launch or worse, be deleted!).

For the keyboard, I use some of "Big Blue's" Rigid Cleaning Tools ["RCT"] (IBM's Part / FRU # 2200574), along with a mild solution of dishwashing detergent in warm water.

Lightly soak one end of the RCT, run it between a section of keys, then dry with opposite side of the RCT. do the same on key faces and other dirty places.
Blow out keyboard with whatever is convenient (I use either compressed air or the exhaust end of a shop vac). Wait about 10 minutes so everything is dry, then power up the machine.

Works great for cleaning sticky keys that have something foreign (sp??) on them... such as spilled food or drinks.
If keys need to be removed, only pop out 1 or 2, but haven't ran into a keyboard which couldn't be cleaned without removing more than one key (that's when the recycle can looks like a nice place to store it!).

For a mouse, remove the tracking ball by rotating the base keyhole deal-ee / thing-ee.
Clean the ball with mild detergent and cool water (not warm or hot! that makes the ball porous and gooey!). Dry it off and set it aside.
Clean the roller base (which the ball rest against / the part you removed to get the ball out), by lightly soaking in same solution, then rub out the build up with a fine low lint cleaning towel.

Next, take a cotton swab and lightly soak one end in the cool water + detergent solution. Be sure the swab is not oversoaked, or drips.
Run the swab on the build up of lint which accumulates on the "X/Y" rollers inside the mouse device (where the ball contacts the rotating assembly(s)), along with the tensioning roller.
With either a tooth pick or tweezers, lift off the lint buildup from each of the three contacting points. Additional presoaking may be required for stubborn lint buildup.
After all lint is removed, run a clean swab, lightly soaked in solution, across all contacting points - until no dirt or lint is remaining.

Prior to reassembly, turn mouse over (as in normal operating direction - with the ball facing downwards), then lightly tap and shake the mouse, in order to dislodge any loose chunks of debris. Now clean the left and right mouse buttons, along with any other function buttons (like scroll wheel). Use a clean towel and the same water/detergent solution, making sure not to oversoak the towel.
Run the towel around the entire grip surface too. Wipe dry then blow out buttons, etc.
Lastly, clean the contacting surfaces on the bottom of the mouse, using the same solution. Towel dry, but do not blow dry!
Replace track ball, reset the base, then clean up your mess before powering up the PC! [Linked Image]

Be sure to clean your mouse pad too!

Scott35

p.s. let me know if this helps!

Scott " 35 " Thompson
Just Say NO To Green Eggs And Ham!