If money were no object (hey, I can dream) and were the appropriate hardware available, I would go for a series combination of breakers and fuses, coordinated so that the breaker would trip on overloads, but the fuse would open on solid faults or breaker failures.
Fuses have benefits, but I've yet to see a GFI fuse, and overfusing because of nuisance tripping is a real danger; hardware failures are real, but human failures are even more common. With enough money, I'd want the best of both worlds.
-Jon
