wirewiz,
Great question. The simple answer is no provided the fuse does not see any overcurrents and is properly sized. That being said, nuisance opening could be a problem due to a couple of reasons. The most common is sizing the fuse too close to a load that has a high inrush current. This can occur in a motor or transformer application that has an unusually high inrush. Also, if you have a three-phase installation and two of three fuses open, there is a chance that the third fuse, which did not open has been somewhat fatigued. That is why it is always recommended to replace all three fuses, and all with the same manufacturer.
The good thing is that fuses only open when excess current is present and they always open the circuit when that overcurrent is present. This greatly improves the reliability and protection of the system over time. It is certainly better than having a device that doesn't trip when it should.
