Of course it's safe ... just how else would one replace a fuse?
Well....when a fuse is blown, it no longer transmits current. When a fuse is not blown, it does. My thoughts were perhaps if I were to unscrew the fuse with it still transferring current, it might emit an arc of electricity. I suppose I could try to locate all the appliances on that one curcuit and unplug them before unscrewing the live fuse....or just pull the main, but I wanted to avert both if at all possible. I didn't mean for it to sound like such a stupid question. Just that I'm used to dealing with flip type circuit breakers, and not with 58 year old fuse boxes. I didn't want to just reach in there and start unscrewing fuses unless there was some sort of precaution to follow first. Of course now that I think about it, the same probably happens when you flip a breaker while something is in operation.