wa2ise, very well said... a 4-wire circuit is still a "circuit", and one would consider it common sense to apply like loads, not say sensitive AV equip, and HVAC. Or a MIG welding rig and an HDTV... Thats just crazy talk!
Anyway, I'm with Bob on this... It is still there at the panel and service. You could even inheret problems from the building next door... Short of a seperate transformer or the like, you really can not get rid of, aleaviate the voltage portion of harmonics, surges or spikes off the system. The benifit of a 2-wire is that you will reduce the chances of voltage drop related issues due to load, and current portion of harmonics to a greater degree, but even they are still present at the panel although to a lesser degree.