Ditto on knowing the contruction of the cieling. I was in a building where the sprinkler installer hit a post tension cable, and sent it half way out the side of the building. They had to have re-engineering of the floor loading, after X-raying most of the floor.
Hilti makes a really expensive heavy duty under-cutting anchor that is great for this, but check around, 'cause Hilti has some licensed under other names that are less expensive, and the same product. for instance Toggler (TM) is the same as the Hilti toggle bolt, but 3X as much.
And if you use epoxy, blow out the hole, or you're just sticking to dust.
"Well - I oughta....." -Jackie Gleason